作者: Peter J. O'Dwyer , James P. Stevenson , Daniel G. Haller , Nelly Rotman , Bruce J. Giantonio
DOI: 10.1016/S0093-7754(01)90252-0
关键词: Surgery 、 General surgery 、 Colorectal cancer 、 Colonoscopy 、 Medicine 、 Stage (cooking) 、 Regimen 、 Adjuvant therapy 、 Physical examination 、 Salvage therapy 、 Quality of life
摘要: The optimal postoperative follow-up strategy for patients with resected Dukes' Stage B and C colorectal cancer is controversial. Recently published guidelines support a minimal regimen of carcinoembryonic antigen measurements every 2 to 3 months at least years, history physical examination 6 then annually, colonoscopy 5 years. Based on documented practice the part surgeons, this would be regarded as intensive. Analyses relapses following adjuvant therapy an even more aggressive schedule, goal maximizing proportion who may operated curative intent (currently about 20% those relapse). Additional considerations that influence approach such include identification second primary tumors (2% over 7 years observation), known improvement in quality life survival associated early versus delayed initiation chemotherapy. However, annual investment resources estimated high 175 million dollars United States alone, systematic study interventions needed provide survival, life, economic evidence.