Microparticles released by human neutrophils adhere to erythrocytes in the presence of complement

摘要: The release of cell surface-derived microparticles, or ectosomes, has now been described for many different types. In various diseases characterized by systemic inflammation, the numbers ectosomes released from specific cell-types are found increased manifold in circulation. Their pro-inflammatory and pro-coagulant functions make them potentially important actors disease establishment and/or progression. Until now, have believed to be free Herein, we provide evidence sequestration derived human polymorphonuclear neutrophils erythrocytes, similarly immune complexes. We show that activate bind complement vitro. whole blood, opsonization mediated their adherence erythrocytes through receptor 1. Taken together, our data suggest an role sequestration, possibly clearance, blood-borne stemming neutrophils. here may modify biological activity function ectosomes.