Functional imaging of the interaction between gut microbiota and the human host: A proof-of-concept clinical study evaluating novel use for 18F-FDG PET-CT.

摘要: Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation short chain fatty acids (SCFA) production and glucose utilization. We sought evaluate 18F-FDG PET-CT as a novel technique for functional imaging alterations in metabolism result the interaction between human host. conducted prospective study healthy humans underwent sampling before after orally administered broad-spectrum antibiotics. The primary outcomes were total regional physiologic colonic uptake (measured mean max standardized values [SUVmean SUVmax]). significant increases all participants following antibiotic treatment 4-5log reduction bacterial load. increase SUVmax was 0.63±0.37 SD (p = 0.004) median 0.42 with an IQR 0.40–0.81. SUVmean 0.31±0.24 0.01) 0.41 0.06–0.55. A likely explanation this phenomenon shift colonocyte glycolysis due shortage SCFA.