Excitatory amino acid receptor subtype binding following traumatic brain injury
作者： L.P. Miller , B.G. Lyeth , L.W. Jenkins , L. Oleniak , D. Panchision
DOI: 10.1016/0006-8993(90)90254-9
关键词: Kainate receptor 、 Biology 、 AMPA receptor 、 Endocrinology 、 NMDA receptor 、 Glutamate receptor 、 Internal medicine 、 Glutamate binding 、 Kainic acid 、 Neocortex 、 Neuroscience 、 Hippocampal formation
摘要: Sprague-Dawley rats were subjected to a moderate level (2.2 atm) of traumatic brain injury (TBI) using fluid percussion. Injured animals allowed post-trauma survival periods 5 min, 3 and 24 h. Regional glutamate receptor subtype binding was assessed with quantitative autoradiography in each group for N-methyl-D-aspartate (NMDA), quisqualate kainate subpopulations at approximately the -3.8 bregma compared sham control group. [3H]glutamate NMDA significantly (P less than 0.05) decreased h post-TBI hippocampal CA1 stratum radiatum, molecular layers dentate gyri outer (layers 1-3) inner 6) overlying neocortex. reduced 6 neocortex all times but no further differences seen hippocampi. No significant changes observed [3H]AMPA receptors [3H]KA only after TBI. These data confirm pathological involvement complex regions selectively vulnerable levels TBI this model.
elsevier.com
sci-hub.se 参考文章(20)
S. Miyazaki, P. G. Newlon, S. J. Goldberg, L. W. Jenkins, B. G. Lyeth, Y. Katayama, R. L. Hayes, Cerebral Concussion Suppresses Hippocampal Long-term Potentiation (LTP) in Rats Springer, Berlin, Heidelberg. pp. 651- 653 ,(1989) , 10.1007/978-3-642-73987-3_169
RONALD L. HAYES, HENRY H. STONNINGTON, BRUCE G. LYETH, CLIFTON E. DIXON, TAKAMITSU YAMAMOTO, Metabolic and Neurophysiologic Sequelae of Brain Injury: A Cholinergic Hypothesis Central nervous system trauma : journal of the American Paralysis Association. ,vol. 3, pp. 163- 173 ,(1986) , 10.1089/CNS.1986.3.163
E Westerberg, DT Monaghan, H Kalimo, CW Cotman, TW Wieloch, Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia The Journal of Neuroscience. ,vol. 9, pp. 798- 805 ,(1989) , 10.1523/JNEUROSCI.09-03-00798.1989
R.L. HAYES, L.W. JENKINS, B.G. LYETH, R.L. BALSTER, S.E. ROBINSON, G.L. CLIFTON, J.F. STUBBINS, H.F. YOUNG, Pretreatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury. Journal of Neurotrauma. ,vol. 5, pp. 259- 274 ,(1988) , 10.1089/NEU.1988.5.259
Steven M. Rothman, John W. Olney, Excitotoxity and the NMDA receptor Trends in Neurosciences. ,vol. 10, pp. 299- 302 ,(1987) , 10.1016/0166-2236(87)90177-9
B.G. Lyeth, C.E. Dixon, L.W. Jenkins, R.J. Hamm, A. Alberico, H.F. Young, H.H. Stonnington, R.L. Hayes, Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Research. ,vol. 452, pp. 39- 48 ,(1988) , 10.1016/0006-8993(88)90006-6
L.W. JENKINS, B.G. LYETH, W. LEWELT, K. MOSZYNSKI, D.S. DEWITT, R.L. BALSTER, L.P. MILLER, G.L. CLIFTON, H.F. YOUNG, R.L. HAYES, Combined pretrauma scopolamine and phencyclidine attenuate posttraumatic increased sensitivity to delayed secondary ischemia. Journal of Neurotrauma. ,vol. 5, pp. 275- 287 ,(1988) , 10.1089/NEU.1988.5.275
B.G. Lyeth, C.E. Dixon, R.J. Hamm, L.W. Jenkins, H.F. Young, H.H. Stonnington, R.L. Hayes, Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat Brain Research. ,vol. 448, pp. 88- 97 ,(1988) , 10.1016/0006-8993(88)91104-3
G.L. Collingridge, T.V.P. Bliss, NMDA receptors - their role in long-term potentiation Trends in Neurosciences. ,vol. 10, pp. 288- 293 ,(1987) , 10.1016/0166-2236(87)90175-5
C.W. Cotman, L.L. Iversen, Excitatory amino acids in the brain - focus on NMDA receptors Trends in Neurosciences. ,vol. 10, pp. 263- 265 ,(1987) , 10.1016/0166-2236(87)90170-6