A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease.
作者： J.O. Rinne , Tuula Myllykyla¨ , Pirkko Lo¨nnberg , Pa¨ivi Marjama¨ki
DOI: 10.1016/0006-8993(91)90588-M
关键词: Endocrinology 、 Nicotinic agonist 、 Temporal cortex 、 Nicotine 、 Muscarinic acetylcholine receptor 、 Hippocampus 、 Psychology 、 Caudate nucleus 、 Alzheimer's disease 、 Internal medicine 、 Parkinson's disease
摘要: Brain nicotinic receptors were studied in the frontal cortex, temporal hippocampus and caudate nucleus patients with Parkinson's disease (PD), Alzheimer's (AD) control. The Bmax Kd values of (-)-[3H]nicotine binding determined a Scatchard analysis. number declined both PD AD all brain areas examined. unchanged. There was negative correlation between degree dementia cortex. A similar seen muscarinic/nicotinic receptor ratio cortex patients. present findings indicate that are affected not only AD, but also dysfunction cholinergic system is involved process PD.
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sci-hub.se 参考文章(28)
R. Quirion, J.C. Martel, Y. Robitaille, P. Etienne, P. Wood, N.P.V. Nair, S. Gauthier, Neurotransmitter and receptor deficits in senile dementia of the Alzheimer type. Canadian Journal of Neurological Sciences. ,vol. 13, pp. 503- 510 ,(1986) , 10.1017/S0317167100037215
ANN E. TAYLOR, J. A. SAINT-CYR, A. E. LANG, Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow. Brain. ,vol. 109, pp. 845- 883 ,(1986) , 10.1093/BRAIN/109.5.845
Edward D. Levin, Jed E. Rose, Susan R. McGurk, Larry L. Butcher, Characterization of the cognitive effects of combined muscarinic and nicotinic blockade. Behavioral and Neural Biology. ,vol. 53, pp. 103- 112 ,(1990) , 10.1016/0163-1047(90)90865-4
Shun Shimohama, Takashi Taniguchi, Motohatsu Fujiwara, Masakuni Kameyama, Biochemical Characterization of the Nicotinic Cholinergic Receptors in Human Brain: Binding of (?)-[3H]Nicotine Journal of Neurochemistry. ,vol. 45, pp. 604- 610 ,(1985) , 10.1111/J.1471-4159.1985.TB04029.X
Paul B.S. Clarke, Agu Pert, Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons Brain Research. ,vol. 348, pp. 355- 358 ,(1985) , 10.1016/0006-8993(85)90456-1
Agneta Nordberg, Abdu Adem, John Hardy, Bengt Winblad, Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains Neuroscience Letters. ,vol. 86, pp. 317- 321 ,(1988) , 10.1016/0304-3940(88)90503-4
Keith Wesnes, David M. Warburton, Effects of scopolamine and nicotine on human rapid information processing performance. Psychopharmacology. ,vol. 82, pp. 147- 150 ,(1984) , 10.1007/BF00427761
Juha O. Rinne, Pirkko Lo¨nnberg, Pa¨ivi Marjama¨ki, Urpo K. Rinne, Brain muscarinic receptor subtypes are differently affected in Alzheimer's disease and Parkinson's disease Brain Research. ,vol. 483, pp. 402- 406 ,(1989) , 10.1016/0006-8993(89)90188-1
D.J.K. Balfour, The effects of nicotine on brain neurotransmitter systems Pharmacology & Therapeutics. ,vol. 16, pp. 269- 282 ,(1982) , 10.1016/0163-7258(82)90058-4
Kenneth J Kellar, Peter J Whitehouse, Andrea M Martino-Barrows, Kendall Marcus, Donald L Price, None, Muscarinic and nicotinic cholinergic binding sites in alzheimer's disease cerebral cortex Brain Research. ,vol. 436, pp. 62- 68 ,(1987) , 10.1016/0006-8993(87)91556-3