Penetrating the cell membrane, thermal targeting and novel anticancer drugs: the development of thermally targeted, elastin-like polypeptide cancer therapeutics
作者： Jung Su Ryu , Marija Kuna , Drazen Raucher
DOI: 10.4155/TDE.14.14
关键词: Protein engineering 、 Cancer 、 Cell membrane 、 Liposome 、 Pharmacology 、 Elastin 、 Drug carrier 、 Angiogenesis 、 Cancer research 、 Chemistry 、 Cell 、 Pharmaceutical Science
摘要: Therapeutic peptides offer important cancer treatment approaches. Designed to inhibit oncogenes and other oncoproteins, early therapeutic applications were hampered by pharmacokinetic properties now addressed through tumor targeting strategies. Active with environmentally responsive biopolymers or macromolecules enhances therapeutics accumulation at sites; passive macromolecules, liposomes, exploits angiogenesis poor lymphatic drainage preferentially accumulate within tumors. Genetically engineered, thermally-responsive, elastin-like polypeptides use both strategies cell-penetrating further intratumoral cell uptake. This review describes the development application of peptide-elastin-like polypeptide for thermally targeted delivery peptides.
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