Perspectives in S-100 protein biology

摘要: Abstract The S-100 protein family constitutes a subgroup of Ca2+-binding proteins the EF-hand type comprising three dimeric isoforms, S-100a0, S-100a and S-100b, plus number structurally related displaying 28–55% homology with subunits. was discovered in 1965; yet, its biological functions have not been fully elucidated. present report will review putative roles protein. Both intracellular extracellular proposed for Within cells, has reported to regulate phosphorylation, ATPase, adenylate cyclase, aldolase activities Ca2+-induced Ca2+ release. Also, cytoskeletal systems, namely microtubules microfilaments be regulated by presence Ca2+. Some molecular targets within identified. This is case microtubule proteins, caldesmon, brain aldolase. secreted; can stimulate neuronal differentiation, glial proliferation, prolactin secretion. However, mechanisms which secreted stimulates above processes are largely unknown. Future research should characterize these latter aspects biology find out linkage between effects activities.