The S-100 Protein Family: A Biochemical and Functional Overview

摘要: The intracellular Ca2+ concentration is closely regulated in eukaryotic cells. of transiently increases from a basal level approximately 0.1 μM as result both flux into the cell extracellular or release stores. This increase by 10- to 100-fold functions an important second messenger signal which may be transduced variety pathways produce Ca2+-mediated physiological response cell. increased needs wide cellular proteins effector molecules various subcellular compartments. These compartments have differing concentrations. targets differ dependent upon type. S-100 are expressed cell-type specific fashion and, therefore, excellent candidates function transducers Ca2+. Cell-cycle progression, differentiation and number responses been demonstrated changes compartment concentration. cell-cycle mediators signal.