Structures of EF-Hand Ca2+-Binding Proteins and Annexins

摘要: The calcium signal is transduced into an intracellular response in part by calcium-binding proteins are thought to be involved the regulation of many cellular activities. These may subdivided two groups with distinct structural features: (A) The modulated proteins, including calmodulin, troponin-C, parvalbumins, S100 and calbindin D-28K (Tables 2.1 2.2). Which share a feature, EFhand (Fig. 2.1, top). (B) The annexin protein family, whose members interact phospholipids membranes calcium-dependent manner. show high degree sequence homology repetitive conserved sequence. This segment 70 amino acid residues includes site for binding association bottom). A common nomenclature has recently been proposed these which have previously known as lipocortins, calcimedins, calpactins, or chromobindins (for see Table 2.3). Their localization functions listed 2.4.