Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis
作者： Allison Walter , Nelly Etienne‐Selloum , David Brasse , Hadeel Khallouf , Christian Bronner
DOI: 10.1096/FJ.09-149419
关键词: Azoxymethane 、 Angiogenesis 、 Aberrant crypt foci 、 Cyclin D1 、 TUNEL assay 、 Tumor suppressor gene 、 In vivo 、 Apoptosis 、 Pharmacology 、 Pathology 、 Biology
摘要: This study evaluated the in vivo antitumor activity of grape-derived polyphenols. BALB/c mice were subcutaneously implanted with C26 colon carcinoma cells, and 2 d later they received either solvent or red wine polyphenols (RWPs) (100 mg/kg/d, human equivalent dose ≈500 mg/d) drinking water for 25 d. Wistar rats RWPs ≈1000 1 wk before injection azoxymethane studied 10 later. In mice, inhibited tumor growth by 31%, reduced vascularization number lung metastases, decreased proliferation as indicated down-regulation Ki67, cyclin D1, UHRF1, increased apoptosis TUNEL staining active caspase-3 levels cells. expression VEGF, matrix metalloproteinase (MMP)-2, MMP-9, cyclooxygenase-2 suppressor genes p16INK4A, p53, p73 rats, 49% azoxy...
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