Long term survival of patients with stage IV gastric carcinoma

摘要: BACKGROUND Survival of patients with Stage IV (based on general rules established by the Japanese Research Society for Gastric Cancer) gastric carcinoma often is unfavorable. Among a poor prognosis, few do survive > 5 years. The authors examined pathologic and biologic features tumors long term survivors. METHODS The analyzed data from 442 carcinoma, including 20 surviving years after gastrectomy (Group A) 422 who died within B). Mutant p53 was immunohistochemically stained using monoclonal antibody PAb1801. Proliferative activity estimated argyrophilic nuclear organizer region (AgNOR) staining proliferating cell antigen (PCNA) staining. RESULTS Group A had smaller more localized than Group B (P < 0.05 P 0.01, respectively). Lymphatic or venous invasion peritoneal dissemination were less frequent in 0.01). Abnormalities expression found 3 14 (21%), value significantly lower 58 118 (49%; 0.05). AgNOR count percentage PCNA labeling not different between Groups B. multivariate analysis showed that lymph node dissection, liver metastasis, resection, invasion, tumor size independent prognostic factors. CONCLUSIONS Even radical extensive dissection can lead to survival. believe combination overexpression predict length survival carcinoma. Cancer 1998;82:2307-2311. © 1998 American Society.