Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates

摘要: BACKGROUND. The American Cancer Society, the Centers for Disease Control and Prevention (CDC), National Institute (NCI), North Association of Central Registries (NAACCR) collaborate annually to provide updated information regarding cancer occurrence trends in United States. This year's report includes colorectal (CRC) incidence death rates highlights use microsimulation modeling as a tool interpreting past projecting future assist control planning policy decisions. METHODS. Information invasive cancers was obtained from NCI, CDC, NAACCR; on deaths CDC's Center Health Statistics. Annual percentage changes age-standardized (based year 2000 US population standard) all combined top 15 were estimated by joinpoint analysis long-term (1975-2006) short-term fixed-interval (1997-2006). All statistical tests 2-sided. RESULTS. Both significantly declined (P < .05) most recent time period men women overall racial ethnic populations. These decreases driven largely declines both 3 common (ie, lung prostate CRC) 2 leading breast CRC). mortality had smaller increases until 2003, when there change nonsignificant decline. Microsimulation demonstrates that CRC are consistent with relatively large contribution screening but demonstrable impact risk factor reductions improved treatments. projected continue if modification, screening, treatment remain at current rates, they could be accelerated further favorable factors higher utilization optimal treatment. CONCLUSIONS. Although decrease is encouraging, rising some concern.