Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

摘要: Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, suggested that cytokines and other peptides are produced, expressed, released by fibers exert paracrine, autocrine, or effects should be classified "myokines." Recent research demonstrates skeletal muscles can produce express belonging to distinctly different families. However, the first most studied myokine is gp130 receptor cytokine interleukin-6 (IL-6). IL-6 was discovered a because of observation it increases up 100-fold in circulation during physical exercise. Identification production activity generated renewed interest metabolic role created paradox. On one hand, markedly produced postexercise period when insulin action enhanced but, on associated with obesity reduced action. This review focuses IL-6, its regulation exercise, signaling pathways muscle, metabolism both health disease.