Anti-muc-1 single chain antibodies for tumor targeting
作者： Sally Joan Denardo , Gerald Louis Denardo , Michelle Denise Winthrop
DOI:
关键词: Tumor targeting 、 Cancer 、 Chemistry 、 Molecular biology 、 Cancer antigen 、 Anti-MUC-1 、 Single-Chain Antibodies 、 Antibody
摘要: This invention provides novel antibodies that specifically bind to the cancer antigen MUC-1. The are useful targeting moieties for directing imaging agents and various thereapeutic a cancer.
lens.org 参考文章(47)
Ilene K. Gipson, Antibody to ocular and vaginal surface epithelium ,(1995)
Jerry A. Peterson, David Larocca, Gary Walkup, Richard Amiya, Roberto L. Ceriani, Molecular Analysis of Epitopic Heterogeneity of the Breast Mucin Springer, Boston, MA. pp. 55- 68 ,(1991) , 10.1007/978-1-4615-3740-3_6
Maria G. Ioannides, Bryan A. Fisk, Constantin G. Ioannides, Methods and compositions for stimulating T-lymphocytes ,(1995)
M. Bud Nelson, Emilio Barberá-Guillem, Compositions and methods for tolerization in immune complex-mediated disease progression ,(1999)
Alvaro Babino, Eduardo Osinaga, Emilio Barbera-Guillem, Compositions for detecting and surgically removing lymphoid tissue involved in tumor progression ,(1999)
L Liebes, M E Noz, E L Kramer, E W Blank, J Melamed, P Furmanski, C Wasserheit, R L Ceriani, A Zabalegui, J A Peterson, Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer. Clinical Cancer Research. ,vol. 4, pp. 1679- 1688 ,(1998)
L H Regimbald, Reddish, L M Pilarski, B M Longenecker, J C Hugh, G Zimmermann, The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer Cancer Research. ,vol. 56, pp. 4244- 4249 ,(1996)
Finn Oj, Kotera Y, Fontenot Jd, Pecher G, Metzgar Rs, Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients Cancer Research. ,vol. 54, pp. 2856- 2860 ,(1994)
Ronald C. Montelaro, Olivera J. Finn, J. Darrell Fontenot, Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof ,(1994)
Emilio Barbera-Guillem, Immunotherapy of b cell involvement in progression of solid, nonlymphoid tumors ,(1999)