Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.
作者： M Aszterbaum , K R Feingold , G K Menon , M L Williams
DOI: 10.1172/JCI116509
关键词: Ceramide 、 Biology 、 Transepidermal water loss 、 Endocrinology 、 Lamellar granule 、 Epidermis (botany) 、 Glucocorticoid 、 Epidermal lamellar body 、 Pulmonary surfactant 、 Stratum corneum 、 Internal medicine
摘要: Abstract The cutaneous permeability barrier to systemic water loss is mediated by hydrophobic lipids forming membrane bilayers within the intercellular domains of stratum corneum (SC). The emerges during day 20 gestation in fetal rat and correlated with increasing SC thickness lipid content, appearance well-formed lamellar bodies epidermis, presence unit structures throughout SC. Because glucocorticoids accelerate lung body surfactant maturation man experimental animals, these studies were undertaken determine whether maternal glucocorticoid treatment accelerates epidermal secretory system. Maternal rats injected betamethasone or saline (control) on days 16-18, pups delivered prematurely 19. Whereas control exhibited immature barriers transepidermal (8.16 +/- 0.52 mg/cm2 per h), glucocorticoid-treated competent (0.74 0.14 h; P < 0.001). Glucocorticoid also: (a) accelerated ultrastructure; (b) increased total content twofold; (c) cholesterol polar ceramide three- sixfold. Thus, functional, morphological, biochemical rat.
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