Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions
作者： W-D Meng , R-X Chu , B-Z Wang , L-P Wang , L-L Ma
DOI: 10.1016/J.PATBIO.2013.02.002
关键词: Helicobacter pylori 、 Gastric mucosa 、 Stomach cancer 、 Immunohistochemistry 、 Cancer 、 Internal medicine 、 Rapid urease test 、 Spirillaceae 、 Biology 、 Gastroenterology 、 Apoptosis
摘要: Abstract Aims There has been limited information about the relations between Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP iASPP in gastric cancer precancerous lesions. Methods H. mucosa were identified by W-S staining rapid urease test. Expression P53, ASPP2 tissues determined immunohistochemistry. Results The concentrations p53 carcinoma group lesion higher than benign diseases ( P positive negative lower Conclusion was a rate infection, an increased expression apoptosis inhibitor iASPP, decreased stimulator or tissues. These results suggest that may cause up-regulating down-regulating ASPP2.
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