Sideritis scardica extracts inhibit aggregation and toxicity of amyloid-β in Caenorhabditis elegans used as a model for Alzheimer’s disease

作者: Felix Heiner , Björn Feistel , Michael Wink

DOI: 10.7717/PEERJ.4683

关键词: Biological activityLamiaceaeCognitive declinePharmacologyCaenorhabditis elegansNeuroprotectionLipophilicityToxicityChemistryPolyphenol

摘要: … and aggregation, which plays a crucial role in the pathogenesis of Alzheimer’s disease. … demonstrated pharmacological activity against characteristics of Alzheimer’s disease also in C. …

参考文章(37)
C. D. Link, Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 9368- 9372 ,(1995) , 10.1073/PNAS.92.20.9368
Shan-Qing Zheng, Ai-Jun Ding, Guo-Ping Li, Gui-Sheng Wu, Huai-Rong Luo, Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different Methods PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0056877
David S. Fay, Amy Fluet, Carolyn J. Johnson, Christopher D. Link, In Vivo Aggregation of β-Amyloid Peptide Variants Journal of Neurochemistry. ,vol. 71, pp. 1616- 1625 ,(2002) , 10.1046/J.1471-4159.1998.71041616.X
D. J. Selkoe, Alzheimer's Disease--Genotypes, Phenotype, and Treatments Science. ,vol. 275, pp. 630- 631 ,(1997) , 10.1126/SCIENCE.275.5300.630
P. T. Lansbury, Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3342- 3344 ,(1999) , 10.1073/PNAS.96.7.3342
Milka Todorova, Antoaneta Trendafilova, None, Sideritis scardica Griseb., an endemic species of Balkan peninsula: Traditional uses, cultivation, chemical composition, biological activity Journal of Ethnopharmacology. ,vol. 152, pp. 256- 265 ,(2014) , 10.1016/J.JEP.2014.01.022
Vanja Tadić, Ivica Jeremic, Silva Dobric, Aleksandra Isakovic, Ivanka Markovic, Vladimir Trajkovic, Dragica Bojovic, Ivana Arsic, Anti-inflammatory, gastroprotective, and cytotoxic effects of Sideritis scardica extracts. Planta Medica. ,vol. 78, pp. 415- 427 ,(2012) , 10.1055/S-0031-1298172