Effect of orientation and density of nanotopography in dermal wound healing
作者： Hong Nam Kim , Yoonmi Hong , Min Sung Kim , Sun Min Kim , Kahp-Yang Suh
DOI: 10.1016/J.BIOMATERIALS.2012.08.038
关键词: Nanotopography 、 Materials science 、 Proliferation rate 、 Extracellular matrix 、 Fibroblast 、 Scaffold 、 Biomedical engineering 、 Wound healing 、 Dermis 、 Cell division
摘要: We report on the effect of synthetic extracellular matrix (ECM) scaffold in form uniformly-spaced nanogrooved surfaces dermal wound healing. The rate coverage was measured various nanotopographical densities with vertical or parallel orientation using nanogrooves 550 nm width three different gaps 550, 1100, and 2750 (spacing ratio: 1:1, 1:2 1:5). Guided by cues absence growth factors healing process, cultured NIH-3T3 cells demonstrated distinctly migration speed, cell division, ECM production as dictated topographical density orientation, whereas proliferation turned out to be nearly same. Based our experimental results, nanopattern spacing ratio yielded best performance terms which seems similar natural organization collagen fibers.
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