Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies.

摘要: Plasmodium falciparum represents one of the strongest selective forces on human genome. This stable and perennial pressure has contributed to progressive accumulation in exposed populations genetic adaptations malaria. Descriptive epidemiology provides initial step a logical procedure consequential phases spanning from identification genes involved resistance/susceptibility diseases, determination underlying mechanisms finally possible translation acquired knowledge new control tools. In malaria, rational development this strategy is traditionally based complementary interactions heterogeneous disciplines going vaccinology passing through genetics, pathogenesis immunology. New tools including expression profile analysis genome-wide association studies are recently available explore complex host-parasite co-evolution. Particularly, combination with large multi-centre initiatives can overcome limits previous results due local population dynamics. Thus, we anticipate substantial advances interpretation validation effects variation malaria susceptibility, thereby molecular protective immune responses pathogenesis.