Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.
作者： Gerhard Lang , Maya I. Mitova , Gill Ellis , Sonia van der Sar , Richard K. Phipps
DOI: 10.1021/NP0504917
关键词: Biological activity 、 Cyclic peptide 、 Stereochemistry 、 Gliocladium 、 Absolute configuration 、 Microtiter plate 、 High-performance liquid chromatography 、 Antibacterial agent 、 Biology 、 Metabolite 、 Chromatography
摘要: Using HPLC/microtiter-plate-based generation of activity profiles the extract a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) well gliotide (3), new cyclodepsipeptide containing several d-amino acids. The absolute configuration 1 elucidated by reduction 2, two further oxidized derivatives (5, 6) were prepared evaluated for biological activity.
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