The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma.
作者： Chunhua Xu , Yue Liu , Limin Xiao , Changgui Guo , Shengze Deng
DOI: 10.1007/S13277-015-4481-0
关键词: CXCR4 、 U87 、 Cancer research 、 Pathology 、 Cell cycle checkpoint 、 AGR2 、 Medicine 、 Stromal cell-derived factor 1 、 Stromal cell 、 PI3K/AKT/mTOR pathway 、 Epithelial–mesenchymal transition
摘要: In recent years, it has been widely identified that the stromal cell-derived factor 1 (SDF-1) and anterior gradient 2 (AGR2) were implicated in development of epithelial-mesenchymal transition (EMT) a variety cancers. However, involvement SDF-1-AGR2 pathway EMT glioblastoma not investigated. present study, vitro assays used to investigate role AGR2 cell cycle, migration, invasion. We found expressions chemokine (C-X-C motif) receptor 4 (CXCR4) obviously upregulated cells T98G, A172, U87, U251 than those normal human astrocytes (NHA) (all p 0.05). Western blot revealed SDF-1 induced expression p-AKT, AGR2, markers (N-cadherin, matrix metalloproteinase-2 (MMP2), Slug) dose-dependent manner U87 cells. depletion reversed SDF-1-induced upregulation rather p-AKT. Furthermore, functional analysis knockdown cycle arrest G0/G1 phase suppressed migration invasion Taken together, SDF-1-CXCR4 control progression likely via AKT glioblastoma. Our findings lay promising foundation for axis-targeting therapy patients with
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