Retraction Note to: The Clinical Utility of Matrix Metalloproteinase 9 in Evaluating Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis.

摘要: In the recent years, matrix metalloproteinase 9 (MMP-9) has been focused on as an indicator of glioma grade and prognosis, especially in China. However, all results resulted many conflicts. So, it is necessary to conduct a meta-analysis secure convincing correlation between MMP-9 prognosis. Eligible studies were included via multiple searches, then odds ratios (ORs) hazard (HRs) with 95 % confidence intervals (95 CIs) estimated. Funnel plots available for evaluation publication bias. addition, heterogeneity sensitivity also analyzed. present meta-analysis, 23 articles allowed inclusion total 1,635 patients. Coincidentally, conducted Chinese populations. High expression gliomas was closely associated high WHO (III+IV) (n = 22, OR 5.25, CI 4.09–6.73; p 0.000), while did not correlate age 4, 1.02, 0.67–1.54; 0.929) gender 5, 0.91, 0.63–1.33; 0.632). Besides, overall survival analysis from two revealed significantly predicted 5-year-OS (HR 6.44, 3.88–10.70; 0.000) No bias observed across studies. To conclude, this suggests potently poor 5 years test tissues should be established department pathology routine clinical practice.