The structural basis of peptide-protein binding strategies.
作者： Nir London , Dana Movshovitz-Attias , Ora Schueler-Furman
DOI: 10.1016/J.STR.2009.11.012
关键词: Peptide sequence 、 Hydrogen bond 、 Binding energy 、 Protein structure 、 Plasma protein binding 、 Signal transduction 、 Binding site 、 Biochemistry 、 Peptide 、 Biophysics 、 Chemistry
摘要: Peptide-protein interactions are very prevalent, mediating key processes such as signal transduction and protein trafficking. How can peptides overcome the entropic cost involved in switching from an unstructured, flexible peptide to a rigid, well-defined bound structure? A structure-based analysis of peptide-protein interactions unravels that most peptides do not induce conformational changes on their partner upon binding, thus minimizing the entropic cost of binding. Furthermore, peptides display interfaces that are better packed than protein …
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Michael Slutsky, Mehran Kardar, Leonid Mirny, Diffusion in correlated random potentials, with applications to DNA. Physical Review E. ,vol. 69, pp. 061903- ,(2004) , 10.1103/PHYSREVE.69.061903
W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific. ,(2002)
Benjamin J. Killian, Joslyn Yudenfreund Kravitz, Sandeep Somani, Paramita Dasgupta, Yuan-Ping Pang, Michael K. Gilson, Configurational Entropy in Protein–Peptide Binding:: Computational Study of Tsg101 Ubiquitin E2 Variant Domain with an HIV-Derived PTAP Nonapeptide Journal of Molecular Biology. ,vol. 389, pp. 315- 335 ,(2009) , 10.1016/J.JMB.2009.04.003
Ross Ihaka, Robert Gentleman, R: A Language for Data Analysis and Graphics Journal of Computational and Graphical Statistics. ,vol. 5, pp. 299- 314 ,(1996) , 10.1080/10618600.1996.10474713
Lei Zhao, Jean Chmielewski, Inhibiting protein-protein interactions using designed molecules. Current Opinion in Structural Biology. ,vol. 15, pp. 31- 34 ,(2005) , 10.1016/J.SBI.2005.01.005
Sebastian Springer, Klaus Döring, Jonathan C. A. Skipper, Alain R. M. Townsend, Vincenzo Cerundolo, Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding. Biochemistry. ,vol. 37, pp. 3001- 3012 ,(1998) , 10.1021/BI9717441
Evangelia Petsalaki, Alexander Stark, Eduardo García-Urdiales, Robert B. Russell, Accurate Prediction of Peptide Binding Sites on Protein Surfaces PLoS Computational Biology. ,vol. 5, pp. e1000335- ,(2009) , 10.1371/JOURNAL.PCBI.1000335
Jennifer A. Zarutskie, Aaron K. Sato, Mia M. Rushe, Iat C. Chan, Aleksey Lomakin, George B. Benedek, Lawrence J. Stern, A Conformational Change in the Human Major Histocompatibility Complex Protein HLA-DR1 Induced by Peptide Binding † Biochemistry. ,vol. 38, pp. 5878- 5887 ,(1999) , 10.1021/BI983048M
Amelie Stein, Patrick Aloy, Contextual Specificity in Peptide-Mediated Protein Interactions PLoS ONE. ,vol. 3, pp. e2524- ,(2008) , 10.1371/JOURNAL.PONE.0002524
William Dall'Acqua, Ellen R. Goldman, Edward Eisenstein, Roy A. Mariuzza, A Mutational Analysis of the Binding of Two Different Proteins to the Same Antibody Biochemistry. ,vol. 35, pp. 9667- 9676 ,(1996) , 10.1021/BI960819I