Clinical Relevance of KRAS in Human Cancers
作者： Sylwia Jančík , Jiří Drábek , Danuta Radzioch , Marián Hajdúch , None
DOI: 10.1155/2010/150960
关键词: Bioinformatics 、 Epidermal growth factor 、 KRAS 、 Carcinogenesis 、 Gene 、 Cancer research 、 Viral Oncogene 、 Biology 、 Oncogene 、 Regulation of gene expression 、 Cell
摘要: The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an that encodes a small GTPase transductor protein called KRAS. involved in the regulation of cell division as result its ability to relay external signals nucleus. Activating mutations impair switch between active and inactive states, leading transformation increased resistance chemotherapy biological therapies targeting epidermal growth factor receptors. This review highlights some features summarizes current knowledge mechanism regulation. It also underlines importance activating relation carcinogenesis their diagnostic biomarkers, providing clues regarding human cancer patients' prognosis indicating potential therapeutic approaches.
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