Increased Radiosensitivity in Cells of Two Human Cell Lines Treated with Bystander Medium from Irradiated Repair-Deficient Cells
作者： C. Mothersill , R. J. Seymour , C. B. Seymour
DOI: 10.1667/RR3488.1
关键词: DNA mismatch repair 、 Bystander effect 、 Molecular biology 、 HT29 Cells 、 Radiosensitivity 、 Immunology 、 Cell culture 、 Irradiation 、 Human cell 、 Radioresistance 、 Biology
摘要: Abstract Mothersill, C., Seymour, R. J. and C. B. Increased Radiosensitivity in Cells of Two Human Cell Lines Treated with Bystander Medium from Irradiated Repair-Deficient Cells. Radiat. Res. 165, 26–34 (2006). Radiation-induced bystander factors have been shown to be more toxic if they are medium harvested irradiated repair-deficient cells. The aim this study was test the hypothesis that radiosensitivity repair-proficient cells can increased by exposing them medium-borne sensitive vice versa. a mismatch repair (MMR)-deficient cell line (Raji 10) response radiation or wild-type parent were 0.5 Gy γ rays then monitored for growth rate their own alternative conditioned medium. In other experiments, added reporter (HPV-G, which relatively keratinocytes, highly radioresistant HT29 cells). subseq...
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James A. Fritzell, Peter M. Glazer, Latha Narayanan, C. Eric Bronner, R. Michael Liskay, Sean M. Baker, Allan Bradley, Susan E. Andrew, Tomas A. Prolla, Frank R. Jirik, Role of DNA mismatch repair in the cytotoxicity of ionizing radiation Cancer Research. ,vol. 57, pp. 5143- 5147 ,(1997)
Seung-Yong Seong, Polly Matzinger, Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses Nature Reviews Immunology. ,vol. 4, pp. 469- 478 ,(2004) , 10.1038/NRI1372
P. Matzinger, The Danger Model Vox Sanguinis. ,vol. 87, pp. 18- 18 ,(2004) , 10.1111/J.1741-6892.2004.00508.X
William F Morgan, Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation? Oncogene. ,vol. 22, pp. 7094- 7099 ,(2003) , 10.1038/SJ.ONC.1206992
POLLY MATZINGER, An Innate Sense of Danger Annals of the New York Academy of Sciences. ,vol. 961, pp. 341- 342 ,(2002) , 10.1111/J.1749-6632.2002.TB03118.X
Chien-Ying Liu, Peter I. Chuang, Chun-Liang Chou, Shu-Min Lin, Hao-Cheng Chen, Paichien Chou, Yun-Hen Liu, Chih-Ten Yu, Chun-Hua Wang, Horng-Chyuan Lin, Han-Pin Kuo, Cytoprotective Response of A1, a Bcl-2 Homologue Expressed in Mature Human Neutrophils and Promyelocytic HL-60 Cells, to Oxidant Stress-Induced Cell Death Journal of Biomedical Science. ,vol. 11, pp. 214- 227 ,(2004) , 10.1007/BF02256565
Michael C Joiner, Philippe Lambin, Brian Marples, Adaptive response and induced resistance Comptes Rendus De L Academie Des Sciences Serie Iii-sciences De La Vie-life Sciences. ,vol. 322, pp. 167- 175 ,(1999) , 10.1016/S0764-4469(99)80040-7
F. M. Lyng, C. B. Semour, C. Mothersill, Early events in the apoptotic cascade initiated in cells treated with medium from the progeny of irradiated cells Radiation Protection Dosimetry. ,vol. 99, pp. 169- 172 ,(2002) , 10.1093/OXFORDJOURNALS.RPD.A006753
Lucia Pirisi, Kim E. Creek, Jay Doniger, Joseph A. Dipaolo, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis. ,vol. 9, pp. 1573- 1579 ,(1988) , 10.1093/CARCIN/9.9.1573
Philip J. Coates, Sally A. Lorimore, Eric G. Wright, Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutation Research. ,vol. 568, pp. 5- 20 ,(2004) , 10.1016/J.MRFMMM.2004.06.042