p53 overexpression correlates with increased survival in patients with squamous carcinoma of the tongue base

摘要: Epidermal growth factor receptor (EGFR), transforming α (TGFA), and p53 are frequently overexpressed in squamous cell carcinomas (SCC) of the upper aerodigestive tract. We chose to study SCC tongue base, which is often advanced at presentation fatal, evaluate whether overexpression correlates with survival. Complete follow-up was available for 20 patients, 18 whom had stage III or IV disease. A number clinical (age, sex, disease) histologic (tumor grade, keratinization, mitotic rate, perineural invasion, lymphatic vascular host response) variables were analyzed. None these correlated Immunohistochemical analysis performed on paraffin-embedded tissue from each patient. Because EGFR TGFA expression routinely found normal epithelium, considered present if greater uptake antibody manifested by a deeper immunostain. In contrast, oncoprotein not detected so detection believed indicate overexpression. 60% tumors, 35%, 20%. Those patients who an mean survival than those did (48 versus 16 months, respectively, p=0.06). This difference significant lesions (p=0.03). correlate may serve as biologic marker indicative improved potential.