In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults.

摘要: Neonates exposed to parasite antigens (Ags) in utero may develop altered fetal immunity that could affect subsequent responses infection. We hypothesized cord blood lymphocytes (CBL) from offspring of mothers residing an area highly endemic for schistosomiasis, filariasis, and tuberculosis Kenya would either fail respond or generate a predominantly Th2-associated cytokine response helminth mycobacterial (PPD) vitro compared maternal PBMC. Kenyan CBL generated Ag-specific IL-5 (range 29-194 pg/ml), IL-10 (121-2,115 and/or IFN-gamma (78 pg/ml-10.6 ng/ml) 26, 46, 57% neonates, respectively (n = 40). PPD induced 30% 79-1,896 but little no IL-4 IL-5. No IL-4, IL-5, release was detected by obtained the United States 11). Ag-driven production primarily CD4-dependent. Cytokine Ags PBMC mirrored observed neonates. infected PPD-sensitized produced more cytokines uninfected (P < 0.05). These data demonstrate human fetus develops similar patterns adults indicates prenatal exposure not lead tolerance immunity. .