Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective, randomized, double-blinded, placebo-controlled, cross-over study

摘要: Although obscure gastrointestinal bleeding cannot be detected by colonoscopy or upper endoscopy, wireless video capsule endoscopy (VCE) is capable of imaging it. Few data are available on medical therapy for patients with nonsteroidal anti-inflammatory drug (NSAID)-induced small-intestinal mucosal injuries. The aim this study was to compare prevention rebamipide and placebo NSAID-induced smallintestinal injury in healthy subjects. Ten subjects who provided written informed consent were enrolled. Rebamipide plus diclofenac administered omeprazole 7 days, an additional 7-day period treatments reversed the same subjects, a 4-week washout between treatments. VCE small intestine performed four times, before after each two periods. number injuries higher group (8/10) than (2/10) (P = 0.023). Two cases ulcer one observed group, while no group. had significantly efficacy preventing injury.