Role of HLA-DR in the pathogenesis of abdominal aortic aneurysm.
作者： G. Moñux , F.J. Serrano , P. Vigil , E.G. De la Concha
关键词: HLA-DR 、 Etiology 、 Pathogenesis 、 Major histocompatibility complex 、 Autoimmunity 、 Allele 、 Abdominal aortic aneurysm 、 Immunology 、 Human leukocyte antigen 、 Medicine
摘要: Abstract Objective: to establish a possible role for autoimmunity in the aetiology of abdominal aortic aneurysm (AAA) by examining human leukocyte antigen class II (HLA-II) immune response genes. Materials and Methods: HLA-II typing was performed series 72 AAA patients control group 380 healthy subjects. Results: higher incidence allele subtype HLA-DR B1 * 0401 detected with respect (12.5 vs 5.2%; p = 0.02, OR 2.59). In contrast, 01 tended behave as protective factor (12.5% 21.3% controls; 0.09, 0.5). Conclusions: association observed here between unspecific is similar that reported several autoimmune diseases. This similarity suggests an essential factors formation AAA. Eur J Vasc Endovasc Surg 26 , 211-214 (2003)
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