Diagnostic Tools for Hypersensitivity to Platinum Drugs and Taxanes: Skin Testing, Specific IgE, and Mast Cell/Basophil Mediators

摘要: Hypersensitivity reactions (HSRs) to platinum drugs and taxanes are increasing in cancer patients, rapid drug desensitization has emerged as a safe effective method reintroduce these reactive patients. Optimal management of patients presenting HSRs chemotherapy depends on the use various diagnostic tools, which include measurement mast cell/basophil mediator release following HSR skin testing. Serum tryptase should be measured HSRs, its elevation would support activation. Skin testing high sensitivity specificity is critical guide platinum-reactive Taxane also emerging useful risk stratification tool evaluation with taxanes. Platinum sIgE assays have been recently developed can helpful combination or an alternative when not available.