Mass Spectrometry-Based N-Glycomics of Colorectal Cancer

摘要: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding CRC pathology warranted to gain insights into underlying and cellular mechanisms disease. Altered protein glycosylation patterns are associated with diseases including malignant transformation. Recent advances in mass spectrometry bioinformatics have accelerated glycomics research present a new paradigm for biomarker discovery. Mass (MS)-based glycoproteomics glycomics, therefore, hold considerable promise improve discovery novel biomarkers utility disease diagnosis therapy. This review focuses on emerging field comprehensive technologies their application studies aimed at discovering glycan-based biomarkers. We will also discuss some challenges using glycans as