Possible Mechanisms of Resistance tocis-Diamminedichloroplatinum (II) of Human Ovarian Cancer Cells
作者： Yoshihiro Kikuchi , Ichiro Iwano , Munenori Miyauchi , Tsunekazu Kita , Michio Sugita
DOI: 10.1111/J.1349-7006.1990.TB02630.X
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摘要: The mechanism of cis-diamminedichloroplatinum (II) (CDDP) resistance was examined by using a CDDP-resistant (KFr) cell line established continuous exposure KF cells (derived from serous cystadenocarcinoma the ovary) to escalating doses CDDP. When KFr were incubated with 66.7 μM CDDP, uptake CDDP significantly inhibited and cellular content in about half that after incubation for 4 h. or h 100 release pattern similar cells. In addition, DNA histogram both revealed seemed contain two clones population may have been selected At 3 intraperitoneal administration 0.5 mg per mouse nude mice tumor, tumor lower than tumor. contrast, at 6 9 higher Furthermore, had cross-resistance various analogues including carboplatin. It shown uptakes into those
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