Lgi4 Promotes the Proliferation and Differentiation of Glial Lineage Cells throughout the Developing Peripheral Nervous System

摘要: The mechanisms that regulate peripheral nervous system (PNS) gliogenesis are incompletely understood. For example, gut neural crest stem cells (NCSCs) do not respond to known gliogenic factors, suggesting yet-unidentified factors gliogenesis. To identify new mechanisms, we performed gene expression profiling secreted by NCSCs during the phase of development. These highly expressed leucine-rich glioma inactivated 4 (Lgi4) despite fact Lgi4 has never been implicated in cell function or enteric is nerve myelination (having identified as mutated spontaneously arising claw paw mutant mice), but play any role PNS development outside nerves. systematically analyze function, generated gene-targeted mice. Lgi4-deficient mice exhibited a more severe phenotype than and had defects sensory, sympathetic, ganglia. We found required for proliferation differentiation glial-restricted progenitors throughout PNS. Analysis compound-mutant revealed mechanism which promotes involves binding ADAM22 receptor. Our results regulating well novel functions maturation glial lineage