Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures.

摘要: Arsenic-containing hydrocarbons (AsHCs), natural products found in seafood, have recently been shown to exert toxic effects human neurons. In this study we assessed the toxicity of three AsHCs cultured astrocytes. Due high cellular accessibility and substantial observed astrocytes were identified as further potential brain target cells for arsenolipids. Thereby, exerted a 5-19-fold higher cytotoxicity compared arsenite. Next arsenicals co-culture model respective Notably did not show any co-culture, while arsenite did. The arsenic studies indicated that protect neurons against accumulation especially after incubation with summary, these data underline importance glial-neuron interaction when assessing vitro neurotoxicity new unclassified metal species.