Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma.

摘要: There is increasing evidence for a role of pulmonary surfactant in asthma and allergic inflammation. In murine models, recent studies have demonstrated that components downregulate the Therefore, we tested hypothesis individuals with mild asthma, natural porcine preparation (Curosurf) given before segmental allergen challenge can reduce airway Ten patients five healthy control subjects were treated two segments either Curosurf or vehicle followed by local challenge. Six additional received one segment as above, but second was instilled without Unexpectedly, treatment augmented eosinophilic inflammation 24 hours after A direct chemotactic effect excluded. However, levels eotaxin interleukin-5 increased bronchoalveo...