Circadian Clock Gene Expression in the Ovary: Effects of Luteinizing Hormone
作者： Bethany N. Karman , Shelley A. Tischkau
DOI: 10.1095/BIOLREPROD.106.050732
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摘要: A molecular device that measures time on a daily, or circadian, scale is nearly ubiquitous feature of eukaryotic organisms. core group clock genes, whose coordinated function required for this timekeeping, expressed both in the central and within numerous peripheral organs. We examined expression genes rat ovary. Transcripts oscillator elements (Arntl, Clock, Per1, Per2, Cry1) were present ovary as indicated by quantitative real-time RT-PCR. Rhythmic patterns Arntl Per2 transcripts protein products out phase with respect to complete antiphase each other. Expression was significantly elevated after LH surge day proestrus. Finally, hCG treatment induced cyclic gene hypophysectomized, immature rats primed eCG. Collectively, these data suggest underpinnings transcriptional/translational feedback loop drives circadian rhythmicity Furthermore, study identifies potential regulator rhythms
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