Methods for determining cancer resistance to histone deacetylase inhibitors

作者: Joseph J. Buggy , Sriram Balasubramanian

DOI:

关键词:

摘要: Described herein are methods and compositions for determining whether a particular cancer is resistant to or susceptible histone deacetylase inhibitor inhibitors. The include analysis of the expression levels at least four biomarker genes associated with response inhibitor. Also described increasing likelihood therapeutically effective treatment in patient, comprising an isolated populations nucleic acids derived from sensitive Further kits indications that optionally used conjunction aforementioned compositions.

参考文章(81)
Masatoshi Narahara, Toshiro Saito, Hiroyuki Tomita, Hirokazu Kato, Jun-ichi Satoh, Takashi Yamamura, Evaluation method of interferon beta treatment against multiple sclerosis ,(2003)
Satinder Ahuja, Handbook of bioseparations Academic Press. ,(2000)
Jonathan A Ellman, Jin Mi Kim, Daniel Goldberg, Non-quinoline inhibitors of malaria parasites ,(2000)
Martin Golebiewski, Bernd Hentsch, Pier Giuseppe Pelicci, Thorsten Heinzel, Saverio Minucci, Alexander B. Maurer, Oliver H. Krämer, Martin Göttlicher, Ping Zhu, The use of molecular markers for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity ,(2003)
Joseph J. Buggy, Erik J. Verner, James Robinson, Chitra Baskaran, Martin Sendzik, Novel hydroxamates as therapeutic agents ,(2004)
Claire M. Banwell, Rena Singh, Paul M. Stewart, Milan R. Uskokovic, Moray J. Campbell, Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation. Recent results in cancer research. ,vol. 164, pp. 83- 98 ,(2003) , 10.1007/978-3-642-55580-0_5
Torsten Haferlach, Martin Dugas, Wolfgang Kern, Claudia Schoch, Susanne Schnittger, Alexander Kohlmann, Method for distinguishing leukemia subtypes ,(2004)
Richard James Bull, Neil Victor Harris, Janet Ann Archer, Stephen Price, David Edward Clark, Walter Bordogna, Marco Van Den Heuvel, Matthew Iain Andrew Gill, Hazel Joan Dyke, Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors ,(2003)