Effect of four combined oral contraceptives on blood pressure in the pill-free interval

作者: Mark Nichols , Gillian Robinson , Walli Bounds , Brian Newman , John Guillebaud

DOI: 10.1016/0010-7824(93)90034-5

关键词:

摘要: Abstract Objective -To evaluate blood pressure changes in the pill-free interval and from baseline among women taking four different low-dose monophasic oral contraceptives. Design -131 were randomized to Pressures obtained at baseline, end of treatment cycles 7 days, during 6 months treatment. 4 8 weeks after discontinuation. Group 1 received norethisterone acetate 1000 μg, group 2 levonorgestrel 150 3 desogestrel gestodene 75 all combined with ethinyloestradiol 30μg. Results -All groups showed an increase treatment, return levels At interval, readings did not differ significantly on except for 4, who experienced diastolic pressure. Conclusions -Use contraceptives was associated a small systolic Whatever mechanism causes is entirely reversible by days without

参考文章(29)
Weijers Mj, Clinical trial of an oral contraceptive containing desogestrel and ethinyl estradiol. Clinical Therapeutics. ,vol. 4, pp. 359- ,(1982)
Korba Vd, Woutersz Tb, Five-year, multicenter study of a triphasic, low-dose, combination oral contraceptive. International Journal of Fertility. ,vol. 33, pp. 406- 410 ,(1988)
Leon Speroff, Marc A. Fritz, Clinical gynecologic endocrinology and infertility ,(1983)
Bernd Düsterberg, Klaus Brill, Clinical acceptability of monophasic gestodene. American Journal of Obstetrics and Gynecology. ,vol. 163, pp. 1398- 1404 ,(1990) , 10.1016/0002-9378(90)91355-G
Ace Lipson, Diane B. Stoy, John C. LaRosa, Richard A. Muesing, Patricia A. Cleary, Valery T. Miller, Peter R. Gilbert, Bruce Stadel, Progestins and oral contraceptive-induced lipoprotein changes: A prospective study Contraception. ,vol. 34, pp. 121- 134 ,(1986) , 10.1016/0010-7824(86)90065-X
K.-T. Khaw, W S Peart, Blood pressure and contraceptive use BMJ. ,vol. 285, pp. 403- 407 ,(1982) , 10.1136/BMJ.285.6339.403