Drospirenone: A novel progestogen with antimineralocorticoid and antiandrogenic activity: Pharmacological characterization in animal models

作者: Peter Muhn , Rolf Krattenmacher , Sybille Beier , Walter Elger , Ekkehard Schillinger

DOI: 10.1016/0010-7824(94)00015-O

关键词:

摘要: … Drospirenone is characterized by a pharmacodynamic profile very closely rei’ated to that of progesterone. The progestogenic activity Iof drospirenone has … In conclusion, drospirenone …

参考文章(20)
J Casals-Stenzel, M Buse, W Losert, Progestogens with antimineralocorticoid activity. Drug Research. ,vol. 35, pp. 459- 471 ,(1985)
F. Neumann, Chemische Konstitution und pharmakologische Wirkung Springer, Berlin, Heidelberg. pp. 680- 1025 ,(1968) , 10.1007/978-3-642-99941-3_6
Mark Nichols, Gillian Robinson, Walli Bounds, Brian Newman, John Guillebaud, Effect of four combined oral contraceptives on blood pressure in the pill-free interval Contraception. ,vol. 47, pp. 367- 376 ,(1993) , 10.1016/0010-7824(93)90034-5
F. Neumann, Pharmacology and potential use of cyproterone acetate. Hormone and Metabolic Research. ,vol. 9, pp. 1- 13 ,(1977) , 10.1055/S-0028-1093574
C. REVESZ, C. I. CHAPPEL, Biological activity of medrogestone: a new orally active progestin. Reproduction. ,vol. 12, pp. 473- 487 ,(1966) , 10.1530/JRF.0.0120473
RICHARD L. LANDAU, KATHLEEN LUGIBIHL, Inhibition of the sodium-retaining influence of aldosterone by progesterone. The Journal of Clinical Endocrinology and Metabolism. ,vol. 18, pp. 1237- 1245 ,(1958) , 10.1210/JCEM-18-11-1237
RICHARD L. LANDAU, DELBERT M. BERGENSTAL, KATHLEEN LUGIBIHL, MARYE. KASCHT, The metabolic effects of progesterone in man. The Journal of Clinical Endocrinology and Metabolism. ,vol. 15, pp. 1194- 1215 ,(1955) , 10.1210/JCEM-15-10-1194
Ulrike Fuhrmann, Christel Bengtson, Gisela Repenthin, Ekkehard Schillinger, Stable transfection of androgen receptor and MMTV-CAT into mammalian cells: inhibition of cat expression by anti-androgens. The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 42, pp. 787- 793 ,(1992) , 10.1016/0960-0760(92)90086-X
W. OELKERS, V. BERGER, A. BOLIK, V. BÄHR, B. HAZARD, S. BEIER, W. ELGER, A. HEITHECKER, Dihydrospirorenone, a New Progestogen with Antimineralocorticoid Activity: Effects on Ovulation, Electrolyte Excretion, and the Renin-Aldosterone System in Normal Women The Journal of Clinical Endocrinology and Metabolism. ,vol. 73, pp. 837- 842 ,(1991) , 10.1210/JCEM-73-4-837