Transfection with bFGF sense and antisense cDNA resulting in modification of malignant glioma growth.

摘要: ✓ Aberrant autocrine control by peptide growth factors is a possible mechanism which disordered regulation of cell proliferation may occur. The authors used the C6 glioma line as model to study role basic fibroblast factor (bFGF) in tumor transfection with bFGF complementary deoxyribonucleic acid both sense and antisense orientation. Clones high messenger ribonucleic expression construct have increased culture levels intracellular extracellular bFGF. show decreased reduced immunologically detectable