Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
作者： Halil Kavgaci , Feyyaz Özdemir , Ercüment Ovali , Aydin Yavuz , Melek Yavuz
DOI: 10.1159/000088954
关键词:
摘要: Background: Ras oncogenes are found in 25% of human tumors and they significantly affect prognosis. One the major fields studied to improve anticancer drugs is blockade on
karger.com
sci-hub.se 参考文章(35)
W. Gillies McKenna, Gary Kao, Eric J. Bernhard, Andrew D. Hamilton, Adrienne D. Cox, Ruth J. Muschel, Said M. Sebti, The Farnesyltransferase Inhibitor FTI-277 Radiosensitizes H-ras-transformed Rat Embryo Fibroblasts Cancer Research. ,vol. 56, pp. 1727- 1730 ,(1996)
Caroline J. Fuery, Tanya L. Applegate, Walter Wouters, Gerard Sanz, Marc Venet, Ann Devine, Stacy Skrzat, Gerda Smets, David W. End, Charles Bowden, Patrick Angibaud, Alison V. Todd, Herve Poignet, Characterization of the Antitumor Effects of the Selective Farnesyl Protein Transferase Inhibitor R115777 in Vivo and in Vitro Cancer Research. ,vol. 61, pp. 131- 137 ,(2001)
Walter A. Korfmacher, Amin A. Nomeir, Jianping Chen, Loretta Nielsen, Lynn Wang, Joseph J. Catino, Matthew S. Bryant, Janet Dell, Suining Lee, Viyyoor M. Girijavallabhan, Paul Kirschmeier, Jameel Syed, Michael Malkowski, Eric Ferrari, W. Robert Bishop, Bohdan Yaremko, Ronald J. Doll, Alan K. Mallams, Arthur G. Taveras, Ming Liu, Dineshwar Sinha, C-C. Lin, Phil Lipari, Stacy Remiszewski, F. George Njoroge, Nicholas Prioli, Antitumor Activity of SCH 66336, an Orally Bioavailable Tricyclic Inhibitor of Farnesyl Protein Transferase, in Human Tumor Xenograft Models and Wap-ras Transgenic Mice Cancer Research. ,vol. 58, pp. 4947- 4956 ,(1998)
Noritsugu Kuranaga, Nariyoshi Shinomiya, Hidetaka Mochizuki, Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an in vitro study. BMC Cancer. ,vol. 1, pp. 10- 10 ,(2001) , 10.1186/1471-2407-1-10
E. J. Bernhard, A. D. Hamilton, Junmin Wu, S. M. Sebti, Yimin Qian, W. G. Mckenna, R. J. Muschel, Inhibiting Ras Prenylation Increases the Radiosensitivity of Human Tumor Cell Lines with Activating Mutations of ras Oncogenes Cancer Research. ,vol. 58, pp. 1754- 1761 ,(1998)
Frédérique Mégnin-Chanet, François Lavelle, Vincent Favaudon, The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution BMC Pharmacology. ,vol. 2, pp. 2- 2 ,(2002) , 10.1186/1471-2210-2-2
Muschel Rj, Bakanauskas Vj, Stanbridge Ej, Bernhard Ej, Cerniglia Gj, McKenna Wg, Gupta Ak, Gupta S, Soto D, Direct Evidence for the Contribution of Activated N-ras and K-ras Oncogenes to Increased Intrinsic Radiation Resistance in Human Tumor Cell Lines Cancer Research. ,vol. 60, pp. 6597- 6600 ,(2000)
David C. Heimbrook, Elaine Rands, Michelle S. Ellis-Hutchings, Hema G. Bhimnathwala, Allen I. Oliff, Charles A. Omer, Nancy E. Kohl, Samuel L. Graham, Samuel V. Machotka, Carolyn A. Buser, Robert B. Lobell, Astrid M. Kral, Theresa M. Williams, Dongming Liu, S. Jane deSolms, Mary Jo Brucker, Joseph P. Davide, Marc T. Abrams, William C. Lumma, Christopher J. Dinsmore, George D. Hartman, Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Research. ,vol. 61, pp. 8758- 8768 ,(2001)
Elizabeth Cohen-Jonathan, Ruth J. Muschel, W. Gillies McKenna, Sydney M. Evans, George Cerniglia, Rosemarie Mick, Donna Kusewitt, Said M. Sebti, Andrew D. Hamilton, Allen Oliff, Nancy Kohl, Jackson B. Gibbs, Eric J. Bernhard, Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS Radiation Research. ,vol. 154, pp. 125- 132 ,(2000) , 10.1667/0033-7587(2000)154[0125:FIPTAE]2.0.CO;2
Nancy E. Kohl, Charles A. Omer, Michael W. Conner, Neville J. Anthony, Joseph P. Davide, S. Jane Desolms, Elizabeth A. Giuliani, Robert P. Gomez, Samuel L. Graham, Kelly Hamilton, Laurence K. Handt, George D. Hartman, Kenneth S. Koblan, Astrid M. Kral, Patricia J. Miller, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Jackson B. Gibbs, Allen Oliff, Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice Nature Medicine. ,vol. 1, pp. 792- 797 ,(1995) , 10.1038/NM0895-792