Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS
作者： Elizabeth Cohen-Jonathan , Ruth J. Muschel , W. Gillies McKenna , Sydney M. Evans , George Cerniglia
DOI: 10.1667/0033-7587(2000)154[0125:FIPTAE]2.0.CO;2
关键词:
摘要: Successful radiosensitization requires that tumor cells become more radiosensitive without causing an equivalent reduction in the survival of surrounding normal tissues. Since cell radiosensitivity can be influenced by RAS oncogene activation, we have hypothesized inhibition oncogenic activity would lead to tumors with activated RAS. We previously showed tissue culture prenyltransferase treatment resulted radiosensitization, whereas wild-type had no effect on radiation survival. Here ask whether findings obtained vitro applicability vivo. found nude mice bearing T24 xenografts farnesyltransferase inhibitors a significant and synergistic after irradiation. The regrowth expressing was also significantly prolonged addition compared irradiation alone. In contrast, there HT-29 These results demonstrate specific oncogenes
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