作者: Daniel Mauvoisin , Loïc Dayon , Frédéric Gachon , Martin Kussmann
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摘要: Proteomic technologies using MS offer new perspectives in circadian biology, particular the possibility to study PTMs. To date, only very few studies have been carried out decipher rhythmicity of protein expression mammals with large-scale proteomics. Although signaling has shown be high relevance, comprehensive characterization PTMs are even more rare. This review aims at describing actual landscape proteomics and opportunities challenges appearing on horizon. Emphasis was given processes for their role metabolic health as regulated by clocks environmental factors. Those expected better deeply characterized coming years