The interplay between antiviral activity, oligonucleotide hybridisation and nucleic acids incorporation studies.
作者： Piet Herdewijn
DOI: 10.1016/J.ANTIVIRAL.2006.04.004
关键词:
摘要: Nucleoside analogues have been the most successful antiviral compounds. Likewise, they are intriguing compounds, because of their structural relationship to natural nucleosides. This is also reason why design process a potential selective nucleoside so difficult. Too many processes (from cellular uptake DNA incorporation) and too enzymes involved in biological effect (activity/toxicity/catabolism/anabolism) make readily predictable. The between physicochemical biochemical properties activity very complex could only be understood on long term basis. Here we try explain some reasoning that was made during leading new potent antivirals with phosphonate functionality.
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