Sectoral variations in the distribution of axonal cytoskeleton proteins in the human optic nerve head.

摘要: Axonal cytoskeleton proteins are intrinsically related to retinal ganglion cell (RGC) health and disease. This study quantifies documents the sectoral distribution of axonal in different laminar compartments normal human optic nerve head (ONH). Nine eyes were used (mean age 46.9 ± 3.7 years). Coronal sections prelaminar, anterior lamina cribrosa, posterior cribrosa retrolaminar regions examined using immunohistochemical confocal microscopy techniques. The was studied antibodies neurofilament light (NFL), medium (NFM), heavy (NFH), phosphorylated NFH (NFHp), microtubule associated protein-1 (MAP-1) tubulin. intensity quantified a standardized manner comparisons made within between regions. NFM, NFHp is significantly greater nasal peripheral sectors There no significant difference NFL, tubulin MAP-1 any region. all unmyelinated than myelinated, region appears be relatively even. may have relevance for understanding vulnerability distinct ONH intraocular pressure- ischaemia-mediated damage. findings this important patho-physiological mechanisms involved glaucomatous ischaemic neuropathy.