Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice.

摘要: Both lithium and valproate are well-established treatments for bipolar disorder. Studies have also found that is effective at reducing suicidal behaviors in patients with mood disorders. Impulsivity a validated endophenotype of both disorder behavior. We assessed effects treatment or on cognitive impulsivity selectively bred mice previously shown to manifest relatively high levels impulsivity. Mice were trained the delay-discounting paradigm, measure reflecting behavioral bias towards immediacy, then treated lithium, valproate, control chow. After 3 weeks drug treatment, tested various delays large, delayed reward. Drug continued during this time. Lithium reduced impulsivity, whereas had no effect choice drugs increased number trials reinforcer intake, but behavior did not depend these motivational changes. To our knowledge, first study demonstrating lithium's reduce Future studies may focus ability putative pharmacotherapies risk suicide modify impulsive dimension diseases.