SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma.
作者： Ji Hyun Chung , Hae Rim Jung , Ah Ra Jung , Young Chan Lee , Moonkyoo Kong
DOI: 10.1038/S41598-018-20086-W
关键词:
摘要: SOX2 copy number and mRNA expression were analysed to examine the clinical significance of activation in HNSCC. Gene signatures reflecting identified an HNSCC cohort. Patients with classified into two subgroups according gene signature: SOX2-high SOX2-low. The was further validated independent cohorts. Moreover, response radiotherapy assessed patients relationship between vitro experiment. subgroup had a better prognosis than SOX2-low all three patient Results multivariate regression analysis showed that signature predictor overall survival (hazard ratio, 1.45; 95% confidence interval, 1.09–1.92; P = 0.01). Interestingly, therapy outcomes receiving radiotherapy. overexpression enhanced effect cell lines. is associated improved might be used predict which benefit from
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