Emerging Cardiovascular Risk Factors That Account for a Significant Portion of Attributable Mortality Risk in Chronic Kidney Disease

摘要: Chronic kidney disease (CKD) increases cardiovascular risk and mortality. However, traditional factors do not adequately account for the substantial increase in mortality observed CKD. The aim of this study was to examine relative contributions novel between CKD population included 4,680 consecutive new patients from a tertiary care preventive cardiology program 1996 2005. Estimated glomerular filtration rate calculated using Modification Diet Renal Disease (MDRD) method. Baseline levels (low-density lipoprotein cholesterol, high-density hypertension, triglycerides, total fasting glucose) emerging (apolipoproteins A-I B, lipoprotein[a], fibrinogen, homocysteine, high-sensitivity C-reactive protein) were examined. All-cause obtained Social Security Death Index. There 278 deaths over median follow-up period 22 months. (estimated ≤60 ml/min/1.73 m2) strongly associated with after adjusting (hazard ratio 2.31, 95% confidence interval 1.77 3.11, p <0.001) addition propensity score 2.33, 1.75 3.10, <0.001). Of all monitored, only homocysteine fibrinogen significantly attenuated association (adjusted hazard 1.73, 1.23 2.34, <0.001), explaining 38% attributable A significant interaction (p = 0.004) estimated whereby annual subjects <10 μmol/L (the bottom tertile) similar those normal renal function (1% per year), whereas ≥12.5 top sevenfold greater risk. In conclusion, explain nearly 40%