Bulky DNA Adducts and Risk of Cancer: A Meta-Analysis
作者： Paolo Vineis , Fabrizio Veglia , Giuseppe Matullo
DOI:
关键词:
摘要: We present a meta-analysis to test the hypothesis that presence of high level bulky DNA adducts in tissues is associated with an increased risk cancer humans. Seven articles were selected matched selection criteria, for total 691 patients and 632 control subjects. In five studies cases had lung cancer, one oral bladder cancer. Six measured WBCs normal tissue around tumor tissue. case-control investigations, was study on nested within cohort. Current smokers showed statistically significant difference between controls, having 83% higher levels than controls (95% confidence interval, 0.44-1.22). Results negative or contradictory ex-smokers nonsmokers. This observation confirmed by sensitivity analyses. Publication bias does not seem be problem. Despite some methodological limitations, our shows current have cancers. conclusion also suggests similar (aromatic) compounds may involved etiology both types
aacrjournals.org
elsevier.com参考文章(22)
Norman E. Breslow, N. E. Day, The analysis of case-control studies International Agency for Research on Cancer. ,(1980)
Meir Stampfer, Meadhbh Ni Shé, Deliang Tang, Jing Ma, Frederica P. Perera, David H. Phillips, Stan Cho, LaVerne A. Mooney, Kathleen J. Cole, Wei-Yann Tsai, Yanzhi Hsu, Association between Carcinogen-DNA Adducts in White Blood Cells and Lung Cancer Risk in the Physicians Health Study Cancer Research. ,vol. 61, pp. 6708- 6712 ,(2001)
J J Hu, M Chandiramani, M Berwick, N Dubin, S Mahabir, G C Roush, R Boorstein, Effects of dietary supplementation of alpha-tocopherol on plasma glutathione and DNA repair activities. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 5, pp. 263- 270 ,(1996)
KAREN T. COPELAND, HARVEY CHECKOWAY, ANTHONY J. McMICHAEL, ROBERT H. HOLBROOK, BIAS DUE TO MISCLASSIFICATION IN THE ESTIMATION OF RELATIVE RISK American Journal of Epidemiology. ,vol. 105, pp. 488- 495 ,(1977) , 10.1093/OXFORDJOURNALS.AJE.A112408
LA Mooney, DA Bell, RM Santella, AM Van Bennekum, R Ottman, M Paik, WS Blaner, GW Lucier, L Covey, Tie-Lan Young, TB Cooper, AH Glassman, FP Perera, Contribution of genetic and nutritional factors to DNA damage in heavy smokers Carcinogenesis. ,vol. 18, pp. 503- 509 ,(1997) , 10.1093/CARCIN/18.3.503
RW Godschalk, LM Maas, N Van Zandwijk, LJ Van't Veer, A Breedijk, PJ Borm, J Verhaert, JC Kleinjans, FJ Van Schooten, Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers Carcinogenesis. ,vol. 19, pp. 819- 825 ,(1998) , 10.1093/CARCIN/19.5.819
M. F. Denissenko, A. Pao, M.-s. Tang, G. P. Pfeifer, Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 Science. ,vol. 274, pp. 430- 432 ,(1996) , 10.1126/SCIENCE.274.5286.430
Y.-W Cheng, C.-Y Chen, P Lin, C.-P Chen, K.H Huang, T.-S Lin, M.-H Wu, H Lee, DNA adduct level in lung tissue may act as a risk biomarker of lung cancer European Journal of Cancer. ,vol. 36, pp. 1381- 1388 ,(2000) , 10.1016/S0959-8049(00)00131-3
Suryanarayana V. Vulimiri, Xifeng Wu, Wanda Baer-Dubowska, Mariza de Andrade, Michelle Detry, Margaret R. Spitz, John DiGiovanni, Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo- 2'-deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations. Molecular Carcinogenesis. ,vol. 27, pp. 34- 46 ,(2000) , 10.1002/(SICI)1098-2744(200001)27:1<34::AID-MC6>3.0.CO;2-G
W. Popp, C. Schell, R. Kraus, C. Vahrenholz, R. Wolf, J. Radtke, K. Bierwirth, K. Norpoth, DNA strand breakage and DNA adducts in lymphocytes of oral cancer patients Carcinogenesis. ,vol. 14, pp. 2251- 2256 ,(1993) , 10.1093/CARCIN/14.11.2251