Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo- 2'-deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations.
作者： Suryanarayana V. Vulimiri , Xifeng Wu , Wanda Baer-Dubowska , Mariza de Andrade , Michelle Detry
DOI: 10.1002/(SICI)1098-2744(200001)27:1<34::AID-MC6>3.0.CO;2-G
关键词:
摘要: The purpose of this study was to examine the level smoking-related aromatic DNA adducts and oxidative damage in current smokers from a lung cancer case-control African Americans Mexican Americans. In addition, mutagen sensitivity (bleomycin-induced chromatid breaks), marker genetic susceptibility, assessed these patients correlated with damage. Lymphocyte cases age-, sex-, ethnicity-matched controls analyzed for (43 47 controls) 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dG) determined 46 48 using 32P-postlabeling. Overall, had significantly (P < 0.05) higher levels 8-oxo-dG (mean±SEM; 6.03±1.16/108 nucleotides 5.82±0.77/105 nucleotides, respectively) compared (2.80±0.36/108 3.65±0.56/105 respectively). differences two biomarkers were especially evident smokers. Both male female corresponding but only men difference statistically significant (P=0.002). Cases who started smoking at earliest age highest 8-oxo-dG. cases, not controls, positively bleomycin-induced breaks (P=0.011). contrast, either or adducts. data suggest that both may be useful predicting risk minority populations. correlation between trend are particularly interesting merit further study. Mol. Carcinog. 27:34–46, 2000. © 2000 Wiley-Liss, Inc.
sci-hub.se 参考文章(66)
Pryor Wa, Cigarette smoke and the involvement of free radical reactions in chemical carcinogenesis The British journal of cancer. Supplement. ,vol. 8, pp. 19- 23 ,(1987)
Goldin R, Rodent models of alcoholic liver disease. International Journal of Experimental Pathology. ,vol. 75, pp. 1- 7 ,(1994)
Qingyi Wei, Margaret R. Spitz, The role of DNA repair capacity in susceptibility to lung cancer: a review. Cancer and Metastasis Reviews. ,vol. 16, pp. 295- 307 ,(1997) , 10.1023/A:1005852211430
K C Cheng, D S Cahill, H Kasai, S Nishimura, L A Loeb, 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. Journal of Biological Chemistry. ,vol. 267, pp. 166- 172 ,(1992) , 10.1016/S0021-9258(18)48474-8
Andrew R. Collins, Catherine M. Gedik, Begoña Olmedilla, Susan Southon, Mary Bellizzi, Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates. The FASEB Journal. ,vol. 12, pp. 1397- 1400 ,(1998) , 10.1096/FASEBJ.12.13.1397
Walter N. Hittelman, Margaret R. Spitz, Qingyi Wei, Donghui Li, Lie Cheng, Mianying Wang, In Vitro Induction of Benzo(a)pyrene Diol Epoxide-DNA Adducts in Peripheral Lymphocytes as a Susceptibility Marker for Human Lung Cancer Cancer Research. ,vol. 56, pp. 3638- 3641 ,(1996)
Margaret R. Spitz, Xifeng Wu, Christopher I. Amos, John F. Annegers, John J. Fueger, T. C. Hsu, A Case-Control Study of Nonrandom Distribution of Bleomycin-induced Chromatid Breaks in Lymphocytes of Lung Cancer Cases Cancer Research. ,vol. 55, pp. 557- 561 ,(1995)
Aage Haugen, Alan Hewer, David Ryberg, David H. Phillips, Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients. Cancer Research. ,vol. 54, pp. 5801- 5803 ,(1994)
K Prasad, J Kalra, A K Chaudhary, Increased production of oxygen free radicals in cigarette smokers. International Journal of Experimental Pathology. ,vol. 72, pp. 1- 7 ,(1991)
R. M. Santella, S. Hearne, F. Perera, T. L. Young, A. Jaretzki, W.-Y. Tsai, J. Mayer, D. Brenner, M. Grimes, H. K. Fischman, S. Grantham, M. X. Tang, Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Cancer Research. ,vol. 49, pp. 4446- 4451 ,(1989)